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The structure of 4,4-dimethylazacyclohexane-2,6-dione (4,4-dimethyl-2,6-piperidinedione)

โœ Scribed by Bocelli, G. ;Grenier-Loustalot, M. F.


Book ID
114527802
Publisher
International Union of Crystallography
Year
1981
Weight
303 KB
Volume
37
Category
Article
ISSN
0567-7408

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The PPA induced Fischer indolization of 4-acetonyl-2,6-piperidinediones 4 takes place both at the methylene and the methyl carbons, although the latter regioisomer (3) undergoes a further cyclization of the imide moiety upon the indole 3position followed by ring-opening of the resulting intermediate