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The stereospecific conversion of P-chiral dialkyl phosphorothioates into [18O]-phosphates

โœ Scribed by Paul M. Cullis

Publisher
Elsevier Science
Year
1983
Tongue
French
Weight
211 KB
Volume
24
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

S-&thy1 thymidine (SP)-3',5'-cyclic phosphorothioate and S-methyl 5'-O+hyaudyl 3'thymidyl (Rp)-phosphorothioate are readily converted by means of sodium ["Ol-hydroxide into the corresponding ["Ol-phosphate diesters stereospecifically with retention of configuration at phosphorus.

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