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Stereospecific conversion of P-chiral nucleoside phosphorothioates into [18O]phosphates

✍ Scribed by Piotr Guga; Andrzej Okruszek

Publisher: Elsevier Science
Year: 1984
Tongue: French
Weight: 210 KB
Volume: 25
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)81320-4

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✦ Synopsis

P-chiral phosphorothioate analogs of thymidine and adenosine nucleotides are transformed in high yield with retention of configuration by [180]chloral and [l80]styrene oxide into corresponding nucleoside [l*O]phosphates. It has been shown in our recent reports that 18 0-labelled reagents such as dimethyl sulphoxide (1) ', styrene oxide (2-j 2 and chloral (z)3 may be successfully applied for a stereospecific conversion of P-chiral cyclic dialkyl phosphorothioates into corresponding 4 [l'O]phosphates

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