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The stereochemistry of reaction of P-chiral dialkyl hydrogen phosphorothioates with [18O]-dimethyl sulphoxide

โœ Scribed by Andrzej Okruszek; Wojciech J. Stec

Publisher
Elsevier Science
Year
1982
Tongue
French
Weight
244 KB
Volume
23
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

Czs-and trans-2-hydroxy-2-thlono-4-methyl-1,3,2-dloxaphosphorlnanes are cleanly transformed by means of [180]-DMSO Into corresponding 2-(['80]-oxo)-derivatives with ca 90% znuerszon of conflguratlon at phosphorus atom.

๐Ÿ“œ SIMILAR VOLUMES

The stereospecific conversion of P-chira
The stereospecific conversion of P-chiral dialkyl phosphorothioates into [18O]-phosphates
โœ Paul M. Cullis ๐Ÿ“‚ Article ๐Ÿ“… 1983 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 211 KB

S-&thy1 thymidine (SP)-3',5'-cyclic phosphorothioate and S-methyl 5'-O+hyaudyl 3'thymidyl (Rp)-phosphorothioate are readily converted by means of sodium ["Ol-hydroxide into the corresponding ["Ol-phosphate diesters stereospecifically with retention of configuration at phosphorus.