The highly stereoselective alkylation (% de=99.6 to 97.6) of a new chiral glycine enolate synthon derived from D-2-phenylglycinol is described. Deprotection of the alkylation adducts in a one-pot, three-step procedure provides the ethyl ester hydrochloride salts of the corresponding a-amino acids wi
β¦ LIBER β¦
The stereoselective synthesis of succinamide derivatives via enolate oxidative coupling
β Scribed by Ned A. Porter; Qi Su; Jill J. Harp; Ian J. Rosenstein; Andrew T. McPhail
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- French
- Weight
- 251 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0040-4039
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## Abstract The procedure provides a simple and efficient method to prepare biologically important quinazoline derivatives.