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Stereoselective alkylation of chiral glycine enolate synthons. The enantioselective synthesis of α-amino acid derivatives.

✍ Scribed by Joseph F. Dellaria Jr.; D.Santarsiero Bernard

Publisher: Elsevier Science
Year: 1988
Tongue: French
Weight: 293 KB
Volume: 29
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)82269-8

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✦ Synopsis

The highly stereoselective alkylation (% de=99.6 to 97.6) of a new chiral glycine enolate synthon derived from D-2-phenylglycinol is described. Deprotection of the alkylation adducts in a one-pot, three-step procedure provides the ethyl ester hydrochloride salts of the corresponding a-amino acids with no attending racemization.

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