Stereoselective nucleophilic addition of chiral lithium enolates to (N-tosyl)imines: enantioselective synthesis of β-aryl-β-amino acid derivatives
✍ Scribed by Zhihua Ma; Yonghua Zhao; Nan Jiang; Xianglin Jin; Jianbo Wang
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- French
- Weight
- 94 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
Nucleophilic addition of the chiral lithium enolates of (S)-(-)-4-benzyl-2-oxazolidinone acetamide with N-tosyl arylaldehyde imines gives b-aryl-b-amino acid derivatives in good yields and excellent diastereoselectivity.
📜 SIMILAR VOLUMES
Chiral N-phosphonyl imines attached by 1-naphthyl group were found to react with lithium malonate enolates smoothly to give chiral b-aminomalonates. Good yields and excellent diastereoselectivity were achieved for sixteen examples. The chiral auxiliary can be readily removed by treating with trifluo
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