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Stereoselective nucleophilic addition of chiral lithium enolates to (N-tosyl)imines: enantioselective synthesis of β-aryl-β-amino acid derivatives

✍ Scribed by Zhihua Ma; Yonghua Zhao; Nan Jiang; Xianglin Jin; Jianbo Wang


Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
94 KB
Volume
43
Category
Article
ISSN
0040-4039

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✦ Synopsis


Nucleophilic addition of the chiral lithium enolates of (S)-(-)-4-benzyl-2-oxazolidinone acetamide with N-tosyl arylaldehyde imines gives b-aryl-b-amino acid derivatives in good yields and excellent diastereoselectivity.


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