Azabicyclic Amino Acids by Stereoselective Dearomatizing Cyclization of the Enolates of N-Nicotinoyl Glycine Derivatives.

Stereoselective alkylation of chiral gly

Stereoselective alkylation of chiral glycine enolate synthons. The enantioselective synthesis of α-amino acid derivatives.

✍ Joseph F. Dellaria Jr.; D.Santarsiero Bernard 📂 Article 📅 1988 🏛 Elsevier Science 🌐 French ⚖ 293 KB

The highly stereoselective alkylation (% de=99.6 to 97.6) of a new chiral glycine enolate synthon derived from D-2-phenylglycinol is described. Deprotection of the alkylation adducts in a one-pot, three-step procedure provides the ethyl ester hydrochloride salts of the corresponding a-amino acids wi