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Synthesis of the bis-diaryl ether fragment of vancomycin via enzymatic oxidative phenolic coupling

✍ Scribed by Ivica Malnar; Charles J Sih

Publisher: Elsevier Science
Year: 2000
Tongue: French
Weight: 176 KB
Volume: 41
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)00058-7

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✦ Synopsis

The bis-diaryl ether cross-linked amino acid fragment, which constitutes the upper part of a vancomycin aglycone framework, was synthesized for the first time using an enzymatic oxidative phenolic coupling methodology. This was achieved via two peroxidase-catalyzed reactions of three amino acid derivatives, 2, 3a, and 4. Other C-O and C-C hetero and homo coupling products were also obtained.

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