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The sodium channel activator Brevetoxin-3 uncovers a multiplicity of different open states of the cardiac sodium channel

โœ Scribed by Wolfgang Schreibmayer; Gerhard Jeglitsch

Book ID
115729964
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
905 KB
Volume
1104
Category
Article
ISSN
0005-2736

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Brevetoxin PbTx-3 and non-toxic derivative 4 were investigated for their abilities to bind to the specific brevetoxin receptor site on rat brain synaptosomes and to modulate the normal function of voltage-gated sodium channels as determined by patch clamping of cultured neurons. Compounds 4 and 5 ar