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Open-Channel Block by the Cytoplasmic Tail of Sodium Channel β4 as a Mechanism for Resurgent Sodium Current

✍ Scribed by Tina M. Grieco; Jyoti D. Malhotra; Chunling Chen; Lori L. Isom; Indira M. Raman

Book ID
116782172
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
494 KB
Volume
45
Category
Article
ISSN
0896-6273

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Internal application of millimolar concentrations of calcium to batrachotoxin (BTX)-activated rat skeletal muscle sodium channels, bathed symmetrically in 200 mM NaCl, causes a reduction in apparent single-channel amplitude without visibly increasing noise at a bandwidth of 50 Hz. A greater calcium-