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State-dependent trapping of flecainide in the cardiac sodium channel

✍ Scribed by Eugene Ramos; Michael E. O'Leary


Book ID
110112813
Publisher
Cambridge University Press
Year
2004
Tongue
English
Weight
305 KB
Volume
560
Category
Article
ISSN
0022-3751

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πŸ“œ SIMILAR VOLUMES


Use dependence of sodium current inhibit
✍ Roland Eickhorn; JΓΆrg Weirich; Daniela Hornung; Hermann Antoni πŸ“‚ Article πŸ“… 1990 πŸ› Springer 🌐 English βš– 943 KB

Tetrodoxin (TTX) is known to cause a voltageand frequency-dependent inhibition of the rapid inward sodium current (IN,) of cardiac muscle. This effect was studied by means of the loose-patch-clamp method on intact rat papillary muscle. The availability curve of the fast sodium system, determined by