The role of tyrosine phosphorylation in the interaction of cellular tyrosine kinases with the T cell receptor ζ chain tyrosine-based activation motif
✍ Scribed by Narin Osman; Susan Lucas; Doreen Cantrell
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 947 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0014-2980
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Tumor necrosis factor-a (TNF-a) can modulate the signalling capacity of tyrosine kinase receptors; in particular, TNF-a has been shown to mediate the insulin resistance associated with animal models of obesity and noninsulin-dependent diabetes mellitus. In order to determine whether the effects of T
## Abstract T cell receptor (TCR) signal transduction is mediated by the immunoreceptor tyrosine‐based activation motifs (ITAM). The ten ITAM in the TCR complex are distributed in two distinct signaling modules termed TCR ζζ and CD3 γϵ/δϵ. To delineate the specific role of the ζ ITAM in T cell deve