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CD2-mediated signaling in T cells lacking the ζ-chain-specific immune receptor tyrosine-based activation (ITAM) motif

✍ Scribed by Christiane Steeg; Arne Von Benin; Hans-Willi Mittrücker; Bernard Malissen; Bernhard Fleischer


Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
774 KB
Volume
27
Category
Article
ISSN
0014-2980

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## Abstract T cell receptor (TCR) signal transduction is mediated by the immunoreceptor tyrosine‐based activation motifs (ITAM). The ten ITAM in the TCR complex are distributed in two distinct signaling modules termed TCR ζζ and CD3 γϵ/δϵ. To delineate the specific role of the ζ ITAM in T cell deve