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The protein interactions of the immunoglobulin receptor family tyrosine-based activation motifs present in the T cell receptor ζ subunits and the CD3 γ,δ and ϵ chains

✍ Scribed by Narin Osman; Helen Turner; Susan Lucas; Karin Reif; Doreen A. Cantrell


Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
664 KB
Volume
26
Category
Article
ISSN
0014-2980

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## Abstract T cell receptor (TCR) signal transduction is mediated by the immunoreceptor tyrosine‐based activation motifs (ITAM). The ten ITAM in the TCR complex are distributed in two distinct signaling modules termed TCR ζζ and CD3 γϵ/δϵ. To delineate the specific role of the ζ ITAM in T cell deve