Tyrosine kinase activity associated with the CD7 antigen: correlation with regulation of T cell integrin function
β Scribed by Anissa S. H. Chan; Pamela J. Reynolds; Yoji Shimizu
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 796 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0014-2980
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
We have previously shown that CD4 ligands inhibit interleukin-2 (IL-2) production and T cell proliferation in human peripheral CD4 + T lymphocytes, in an MHC-independent way. Two major pathways implicated in T cell activation are inhibited by binding of CD4 ligands to the CD4 molecule, i. e. Ca 2+ s
CD7 is a 40-kDa glycoprotein that is expressed on prothymocytes and persists during T cell differentiation. CD7 has been demonstrated to generate, like other costimulatory molecules, intracellular signals that modulate T cell function. However, although it binds to phosphatidylinositol 3-kinase (PI