Rat hepatoma cells rapidly adhered to the polystyrene surfaces of culture bottles. The adhesiveness of the cells was inhibited by sulfhydryl blocking reagents including mercurials, arsenicals, and alkylating agents. Inhibition was prevented, and in some cases reversed, by the addition of dithiothrei
The role of sulfhydryl groups in cellular adhesiveness
β Scribed by John V. George; K. Vasudeva Rao
- Publisher
- John Wiley and Sons
- Year
- 1975
- Tongue
- English
- Weight
- 554 KB
- Volume
- 85
- Category
- Article
- ISSN
- 0021-9541
No coin nor oath required. For personal study only.
β¦ Synopsis
Abstract
Aggregation of chick embryonic liver and kidney cells was completely abolished by a treatment with carboxypyridine disulfide which binds βSH groups. The effect could be reversed by a subsequent treatment with some thiols. Inhibition of RNA synthesis or respiratory metabolism did not prevent cell aggregation. Cell adhesion is discussed in the light of these observations.
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