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The role of sulfhydryl groups in human neutrophil adhesion, movement and particle ingestion

✍ Scribed by Dr. Gerald F. Giordano; Dr. Marshall A. Lichtman

Publisher
John Wiley and Sons
Year
1973
Tongue
English
Weight
705 KB
Volume
82
Category
Article
ISSN
0021-9541

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Recent studies have suggested that ectosulfhydryl groups may play a role in cell contact phenomena.

We have studied the possible role of ecto‐ and endosulfhydryl groups in the morphology, adhesiveness, random and directed (chemotaxis) motility and phagocytosis of human polymorphonuclear neutrophils. The rapidly penetrating sulfhydryl binding reagents HgCl~2~ and NEM inhibited adhesiveness, motility and phagocytosis when studied at > 0.1 mM in plasma or > 0.01 mM in buffer. The difference in inhibitory concentration was shown to be due to the difference in albumin content of the two media. D‐cysteine prevented the effect of HgCl~2~ and NEM on cell morphology, adhesiveness, motility and phagocytosis indicating that their effects were on cell sulfhydryl groups. PCMBS, a very slowly penetrating organic mercurial, had no effect on neutrophil morphology, adhesiveness, motility or phagocytosis. However, PCMBS inhibited platelet aggregation, assuring its potency. These studies indicate that ectosulfhydryl groups are either not present or not participants in the maintainence of structure and functions of human neutrophilic granulocytes.

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