## Abstract Aggregation of chick embryonic liver and kidney cells was completely abolished by a treatment with carboxypyridine disulfide which binds –SH groups. The effect could be reversed by a subsequent treatment with some thiols. Inhibition of RNA synthesis or respiratory metabolism did not pre
Inhibition of cellular adhesiveness by sulfhydryl blocking agents
✍ Scribed by Frederick Grinnell; Paul A. Srere
- Publisher
- John Wiley and Sons
- Year
- 1971
- Tongue
- English
- Weight
- 396 KB
- Volume
- 78
- Category
- Article
- ISSN
- 0021-9541
No coin nor oath required. For personal study only.
✦ Synopsis
Rat hepatoma cells rapidly adhered to the polystyrene surfaces of culture bottles. The adhesiveness of the cells was inhibited by sulfhydryl blocking reagents including mercurials, arsenicals, and alkylating agents. Inhibition was prevented, and in some cases reversed, by the addition of dithiothreitol to the adhesive medium. The current model explaining cellular adhesion is discussed in the light of these observations
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