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The Role of Inter-Cellular Adhesion in the Recirculation of T Lymphocytes

✍ Scribed by Dov J. Stekel

Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
244 KB
Volume
186
Category
Article
ISSN
0022-5193

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✦ Synopsis

We refine an existing model of T lymphocyte recirculation, in order to incorporate a description of the adhesion between T cells and other cell types in the lymphoid tissue, such as dendritic cells. The new model is able to fit the animal experiments on lymphocyte recirculation. It also allows for the variation of these adhesive properties, as would occur in the presence of antigen, and it is shown that it is possible for the T cell counts in blood to reach very low levels, as a result of increased adhesion between T cells and dendritic or other cells present in the lymphoid tissue. We discuss the implications of this phenomenon for HIV infection.

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