Cooperation by mouse T lymphocytes: the role of antibody in T cell specificity

✍ Scribed by J. H. L. Playfair; S. Marshall-Clarke; L. Hudson

• Publisher: John Wiley and Sons
• Year: 1974
• Tongue: English
• Weight: 307 KB
• Volume: 4
• Category: Article
• ISSN: 0014-2980
• DOI: 10.1002/eji.1830040114

✦ Synopsis

Abstract

Mouse thymus cells were educated in vivo with horse red blood cells (RBC) and tested for their ability to cooperate in the response of bone marrow cells to sheep RBC. Significant cooperation was observed only when anti‐sheep serum was injected into the educating mouse. We suggest that cooperation and some other properties of the T cell are mediated by passively acquired antibody.