✦ LIBER ✦

The role of proline in the proteolytic regulation of biologically active peptides

✍ Scribed by A. Yaron

Publisher: Wiley (John Wiley & Sons)
Year: 1987
Tongue: English
Weight: 527 KB
Volume: 26
Category: Article
ISSN: 0006-3525
DOI: 10.1002/bip.360260019

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✦ Synopsis

Specificity studies of the enzymatic hydrolysis of proline-containing peptides give further evidence of the unique nature of the Xaa-Pro bond and indicate its role in the limited proteolysis as a structural element protecting the N-terminal chain end. A sensitive, highly specific fluorogenic assay was developed for aminopeptidase P [EC 3.4.11.91, that specifically cleaves N-terminal Xaa-Pro bonds. Examples of polypeptides with known N-terminal Xaa-Pro sequences are listed and the influence of proline on the proteolytic processing of polypeptide precursors is discussed.

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