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Substituted Prolines: Syntheses and Applications in Structure—Activity Relationship Studies of Biologically Active Peptides

✍ Scribed by Philippe Karoyan; Sandrine Sagan; Olivier Lequin; Jean Quancard; Solange Lavielle; Gerard Chassaing


Publisher
John Wiley and Sons
Year
2006
Weight
8 KB
Volume
37
Category
Article
ISSN
0931-7597

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Following up on the observation that the dynorphin analog [Pro(3)]Dyn A(1-11)-NH(2) 2 possesses high affinity and selectivity for the kappa opioid receptor, a number of related peptides were prepared and characterized by radioligand binding and [(35)S]GTPgammaS assays. While incorporation of 2-azeti