## Synopsis Efforts to understand the chemical-physical basis for peptide hormone and neurotransmitter action requires integration of conformational parameters and biological properties. Since most peptide hormones are conformationally flexible, the question arises as to which of the manifold of c
Conformational and topographical considerations in the design of biologically active peptides
โ Scribed by Victor J. Hruby
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 1993
- Tongue
- English
- Weight
- 833 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0006-3525
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Analogues of alamethicin, a 20-mer amphipathic helical peptide with ionophore activity, in the sequence of which all Aib residues were substituted by Ala (Al) or Leu (Ll), were synthesized by the solid phase method, purified by high performance liquid chromatography and characterized by fast atomic