The role of P-glycoprotein in blood-brain barrier transport of morphine: transcortical microdialysis studies in mdr1a (−/−) and mdr1a (+/+) mice
✍ Scribed by Rujia Xie; Margareta Hammarlund-Udenaes; Albertus G De Boer; Elizabeth C M De Lange
- Book ID
- 110004545
- Publisher
- Nature Publishing Group
- Year
- 1999
- Tongue
- English
- Weight
- 156 KB
- Volume
- 128
- Category
- Article
- ISSN
- 0007-1188
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
In the mouse, both the mdr1a and the mdr1b gene encode drug-transporting P-glycoproteins. The mdr1a P-glycoprotein is expressed in epithelial cells of, among others, the liver and the intestine. Furthermore, the mdr1b gene product is found in the liver but is not detectable in the intestine. To esta
## Abstract A subpopulation of the CF‐1 mouse strain is sensitive to neurotoxicity following exposure to avermectins, a family of structurally related antiparasitic agents. This unusual sensitivity is the result of a deficiency in the mdr1a P‐glycoprotein that normally contributes to a functional b