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Development of an In Situ Mouse Brain Perfusion Model and Its Application to mdr1a P-Glycoprotein-Deficient Mice

✍ Scribed by Dagenais, Claude; Rousselle, Christophe; Pollack, Gary M.; Scherrmann, Jean-Michel


Book ID
110079067
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
417 KB
Volume
20
Category
Article
ISSN
0271-678X

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Development of a P-glycoprotein knockout
✍ Leanne Cutler; Colin Howes; Nigel J. Deeks; Tania L. Buck; Phil Jeffrey πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 219 KB

The objective of this study was to establish the optimal blood concentrations of the potent P-glycoprotein (P-gp) inhibitor GF120918 (Elacridar) required to achieve maximal knockout of this efflux transporter in the blood-brain barrier (BBB) of mice, rats, and guinea pigs. Genetic mdr1a/b(-/-) knock