Development of a P-glycoprotein knockout
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Leanne Cutler; Colin Howes; Nigel J. Deeks; Tania L. Buck; Phil Jeffrey
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Article
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2006
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John Wiley and Sons
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English
β 219 KB
The objective of this study was to establish the optimal blood concentrations of the potent P-glycoprotein (P-gp) inhibitor GF120918 (Elacridar) required to achieve maximal knockout of this efflux transporter in the blood-brain barrier (BBB) of mice, rats, and guinea pigs. Genetic mdr1a/b(-/-) knock