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Increased accumulation of doxorubicin and doxorubicinol in cardiac tissue of mice lacking mdr1a P-glycoprotein

✍ Scribed by Asperen, J van; Tellingen, O van; Tijssen, F; Schinkel, A H; Beijnen, J H


Book ID
110000888
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
55 KB
Volume
79
Category
Article
ISSN
0007-0920

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Contribution of the murine mdr1a P-glyco
✍ Johan W. Smit; Alfred H. Schinkel; Michael MΓΌller; Betty Weert; Dirk K. F. Meije πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 129 KB

In the mouse, both the mdr1a and the mdr1b gene encode drug-transporting P-glycoproteins. The mdr1a P-glycoprotein is expressed in epithelial cells of, among others, the liver and the intestine. Furthermore, the mdr1b gene product is found in the liver but is not detectable in the intestine. To esta