The randomized clinical trial is the gold standard methodology for evaluating treatment interventions. The randomized trial is a prospective experimental study, the embodiment of the scientific method applied to the clinic. Both organizational and ethical considerations encourage the use of formal c
The role of meta-analysis in cancer clinical trials
β Scribed by Chikuma Hamada
- Publisher
- Springer
- Year
- 2009
- Tongue
- English
- Weight
- 217 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1341-9625
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Randomized trials are effective and usually unbiased for showing the average results in a selected outcome variable for treatment A versus treatment B, and meta-analyses produce an average of these averages. The results of both the trials and meta-analyses are often pragmatically unsatisfactory, how
In this paper we discusa empirical Bayes methods for combining evidence from a series of clinical experiments comparing two treatments. The approach is bawd on a random effects model for the treatment effects. We describe two nonparametric empirical Bayes procedures for estimating the effect sizes i