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Empirical Bayes Methods in Clinical Trials Meta-Analysis

✍ Scribed by Dr. Th. Stijnen; Dr. J. C. Van Houwelingen

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 621 KB
Volume: 32
Category: Article
ISSN: 0323-3847
DOI: 10.1002/bimj.4710320316

No coin nor oath required. For personal study only.

✦ Synopsis

In this paper we discusa empirical Bayes methods for combining evidence from a series of clinical experiments comparing two treatments. The approach is bawd on a random effects model for the treatment effects. We describe two nonparametric empirical Bayes procedures for estimating the effect sizes in the individual trials. The empirical Bayes estimates should have smaller mean squared error than the observed effect sizes. Moreover, the empirical Bayes estimates exhibit less variability and are more comparable to each other than the original estimates.

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