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META-ANALYSIS IN THE DESIGN AND MONITORING OF CLINICAL TRIALS

โœ Scribed by REBECCA DERSIMONIAN

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
828 KB
Volume
15
Category
Article
ISSN
0277-6715

No coin nor oath required. For personal study only.

โœฆ Synopsis

Results from external studies often play an important role in many aspects of a clinical trial. Their incorporation into the decision making process of a trial, however, is rarely conducted in a formal manner. This conference will address what formal role, if any, meta-analytic summaries of external results should have in the design and monitoring of an ongoing trial. This introductory presentation describes in detail the example from obstetric research which motivated the conference topic, and, in a Bayesian framework, summarizes the general implications of formally incorporating meta-analytic results into the design and analysis of a new trial.

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โœ NANCY L. GELLER ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 253 KB ๐Ÿ‘ 2 views

was followed by discussion which often required intervention by the moderator, Bill Brown. DerSimonian introduced the topic with an example of a meta-analysis of several trials on calcium supplementation for the prevention of pre-eclampsia. Discussing the wide differences in study design and qualit