Dendritic cells (DCs) are professional antigen-presenting cells that are specialized in the uptake of antigens and their transport from peripheral tissues to the lymphoid organs. Over the last decades, the properties of DCs have been intensely studied and much knowledge has been gained about the rol
The role of dendritic cells in CNS autoimmunity
β Scribed by Alla L. Zozulya; Benjamin D. Clarkson; Sonja Ortler; Zsuzsanna Fabry; Heinz Wiendl
- Publisher
- Springer
- Year
- 2010
- Tongue
- English
- Weight
- 559 KB
- Volume
- 88
- Category
- Article
- ISSN
- 0946-2716
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regarding such properties as the surface electrostatic potential and the physicochemical character of the antigen binding groove, both of which are pivotal in antigenic peptide affinity 8,9 . By contrast, few differences have been found between the molecular properties of HLA-DR alleles deemed susce
## Abstract Autoimmune diseases are characterized by the loss of tolerance toward selfβantigens and the induction of destructive immune responses leading to tissue damage. Most patients with autoimmune diseases are treated with immunosuppressive drugs that suppress the immune response in a nonβspec