Background: Altered intestinal dendritic cell (DC) function underlies dysregulated T-cell responses to bacteria in Crohn's disease (CD) but it is unclear whether composition of the intestinal microbiota impacts local DC function. We assessed the relationship between DC function with disease activity
β¦ LIBER β¦
Dendritic cells and the shadow line between autoimmunity and disease
β Scribed by Angelo A. Manfredi; Maria Grazia Sabbadini; Patrizia Rovere-Querini
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 111 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0004-3591
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## Abstract Dendritic cells (DCs) not only induce but also modulate T cell activation. 1,25βdihydroxyvitamin D~3~ [1,25(OH)~2~D~3~] induces DCs with a tolerogenic phenotype, characterized by decreased expression of CD40, CD80, and CD86 costimulatory molecules, low ILβ12 and enhanced ILβ10 secretion