𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Involvement of dendritic cells in autoimmune diseases in children

✍ Scribed by Consuelo M López de Padilla; Ann M Reed

Publisher
BioMed Central
Year
2007
Tongue
English
Weight
437 KB
Volume
5
Category
Article
ISSN
1546-0096

No coin nor oath required. For personal study only.

✦ Synopsis

Dendritic cells (DCs) are professional antigen-presenting cells that are specialized in the uptake of antigens and their transport from peripheral tissues to the lymphoid organs. Over the last decades, the properties of DCs have been intensely studied and much knowledge has been gained about the role of DCs in various diseases and health conditions where the immune system is involved, particularly in cancer and autoimmune disorders. Emerging clues in autoimmune diseases, suggest that dendritic cell dysregulation might be involved in the development of various autoimmune disorders in both adults and children. However, studies investigating a possible contribution of DCs in autoimmune diseases in the pediatric population alone are scanty. The purpose of this review is to give a general overview of the current literature on the relevance of dendritic cells in the most common autoimmune conditions of childhood.

📜 SIMILAR VOLUMES

Dendritic cells in tolerance induction f
Dendritic cells in tolerance induction for the treatment of autoimmune diseases
✍ Maria Rescigno 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 248 KB 👁 2 views

## Abstract Autoimmune diseases are characterized by the loss of tolerance toward self‐antigens and the induction of destructive immune responses leading to tissue damage. Most patients with autoimmune diseases are treated with immunosuppressive drugs that suppress the immune response in a non‐spec

Do maternal cells trigger or perpetuate
Do maternal cells trigger or perpetuate autoimmune diseases in children?
✍ Anne M Stevens 📂 Article 📅 2007 🏛 BioMed Central 🌐 English ⚖ 281 KB

The placental barrier is not the impenetrable wall that it was once presumed to be. During pregnancy, fetal cells pass into the mother, where they persist for decades after the pregnancy, leading to **__fetal microchimerism__ (FMc**). Maternal cells also pass into the fetus, where they can persist l