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The role of caspases in apoptosis of trophic factor-deprived PC12 cells

โœ Scribed by R. Haviv; L. Lindenboim; R. Stein

Book ID
117476302
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
15 KB
Volume
237
Category
Article
ISSN
0304-3940

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PC12 cells are a useful model system for studying neuronal apoptosis. Like neurons, they undergo apoptosis when deprived of trophic support. Involvement of caspases [interleukin 1โค-converting enzyme (ICE)related proteases] has been implicated in apoptosis induced by various stimuli in many cell type

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Previous studies have shown that caspases (proteases related to interleukin-1โค converting enzyme) are needed for the death of trophic factor-deprived PC12 cells. However, the protease involved in this process has not been identified. The results presented here strongly suggest that caspase-2 (Nedd2/