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Apoptosis in Neuronal Development and Transplantation: Role of Caspases and Trophic Factors

✍ Scribed by Zita Boonman; Ole Isacson


Book ID
115606960
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
289 KB
Volume
156
Category
Article
ISSN
0014-4886

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PC12 cells are a useful model system for studying neuronal apoptosis. Like neurons, they undergo apoptosis when deprived of trophic support. Involvement of caspases [interleukin 1␀-converting enzyme (ICE)related proteases] has been implicated in apoptosis induced by various stimuli in many cell type