Previous studies have shown that caspases (proteases related to interleukin-1โค converting enzyme) are needed for the death of trophic factor-deprived PC12 cells. However, the protease involved in this process has not been identified. The results presented here strongly suggest that caspase-2 (Nedd2/
โฆ LIBER โฆ
Mechanism of ethanol enhancement of apoptosis and caspase activation in serum-deprived PC12 cells
โ Scribed by Wojciech Krzyzanski; Jan Oberdoester; Richard A. Rabin
- Book ID
- 116719178
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 543 KB
- Volume
- 81
- Category
- Article
- ISSN
- 0024-3205
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PC12 cells are a useful model system for studying neuronal apoptosis. Like neurons, they undergo apoptosis when deprived of trophic support. Involvement of caspases [interleukin 1โค-converting enzyme (ICE)related proteases] has been implicated in apoptosis induced by various stimuli in many cell type
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