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The RNA polymerase II carboxy-terminal domain: links to a bigger and better ‘holoenzyme’?

✍ Scribed by Andrew Emili; C James Ingles

Book ID
116165810
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
479 KB
Volume
5
Category
Article
ISSN
0959-437X

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Cdc2 kinase triggers the entry of mammalian cells into mitosis, the only cell cycle phase in which transcription is globally repressed. We show here that Cdc2 kinase phosphorylates components of the RNA polymerase II transcription machinery including the RNA polymerase II carboxy-terminal repeat dom