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BRD4 is an atypical kinase that phosphorylates Serine2 of the RNA Polymerase II carboxy-terminal domain

✍ Scribed by Devaiah, B. N.; Lewis, B. A.; Cherman, N.; Hewitt, M. C.; Albrecht, B. K.; Robey, P. G.; Ozato, K.; Sims, R. J.; Singer, D. S.


Book ID
111644142
Publisher
National Academy of Sciences
Year
2012
Tongue
English
Weight
719 KB
Volume
109
Category
Article
ISSN
0027-8424

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Cdc2 kinase triggers the entry of mammalian cells into mitosis, the only cell cycle phase in which transcription is globally repressed. We show here that Cdc2 kinase phosphorylates components of the RNA polymerase II transcription machinery including the RNA polymerase II carboxy-terminal repeat dom