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Structure of an mRNA Capping Enzyme Bound to the Phosphorylated Carboxy-Terminal Domain of RNA Polymerase II

โœ Scribed by Carme Fabrega; Vincent Shen; Stewart Shuman; Christopher D. Lima

Book ID
117737135
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
727 KB
Volume
11
Category
Article
ISSN
1097-2765

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Cdc2 kinase triggers the entry of mammalian cells into mitosis, the only cell cycle phase in which transcription is globally repressed. We show here that Cdc2 kinase phosphorylates components of the RNA polymerase II transcription machinery including the RNA polymerase II carboxy-terminal repeat dom