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The Response to and Repair of RAG-Mediated DNA Double-Strand Breaks

✍ Scribed by Helmink, Beth A.; Sleckman, Barry P.


Book ID
120406609
Publisher
Annual Reviews
Year
2012
Tongue
English
Weight
357 KB
Volume
30
Category
Article
ISSN
0732-0582

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## Abstract Two mechanisms are available for the repair of DNA double‐strand breaks (DSBs) in eukaryotic cells: homology directed repair (HDR) and non‐homologous end‐joining (NHEJ). While NHEJ is not restricted to a particular phase of the cell cycle, it is incapable of accurately repairing DBSs th