Repair and consequences of double-strand breaks in DNA
β Scribed by Albert Pastink; Paul H.M Lohman
- Book ID
- 114396585
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 160 KB
- Volume
- 428
- Category
- Article
- ISSN
- 0027-5107
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The autosomal recessive genetic disorder, Nijmegen Breakage Syndrome, is characterised by an excessively high risk for the development of lymphatic tumours and an extreme sensitivity towards ionising radiation. The most likely explanation for these characteristics, a deficiency in the repair of DNA
## Abstract Two mechanisms are available for the repair of DNA doubleβstrand breaks (DSBs) in eukaryotic cells: homology directed repair (HDR) and nonβhomologous endβjoining (NHEJ). While NHEJ is not restricted to a particular phase of the cell cycle, it is incapable of accurately repairing DBSs th