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Genomic integrity and the repair of double-strand DNA breaks

✍ Scribed by Albert Pastink; Jan C.J. Eeken; Paul H.M. Lohman


Book ID
114070428
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
134 KB
Volume
480-481
Category
Article
ISSN
0027-5107

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## Abstract Two mechanisms are available for the repair of DNA double‐strand breaks (DSBs) in eukaryotic cells: homology directed repair (HDR) and non‐homologous end‐joining (NHEJ). While NHEJ is not restricted to a particular phase of the cell cycle, it is incapable of accurately repairing DBSs th