The reduced expression and aberrant methylation of p16INK4a in chromate workers with lung cancer
β Scribed by Kondo, Kazuya; Takahashi, Yuji; Hirose, Yukiko; Nagao, Taeko; Tsuyuguchi, Masaru; Hashimoto, Masato; Ochiai, Atsushi; Monden, Yasumasa; Tangoku, Akira
- Book ID
- 119319430
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 430 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0169-5002
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Aberrant promoter methylation of normally unmethylated CpG-islands offers a promising tool for the development of molecular biomarkers. We investigated bronchial aspirates of patients admitted for suspected lung cancer with regard to the prevalence of aberrant methylation of potential marker genes.
Our previous studies revealed a variety of genetic changes in lung cancers from chromate-exposed workers (chromate lung cancer). In the present study, we examined epigenetic changes in chromate lung cancers. Nestedmethylation-specific PCR was employed in studying the methylation of CpG islands in th