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P-281 Detection of aberrant promoter methylation of the p16INK4a and MGMT genes in non-small cell lung cancer patients: a prospective study

โœ Scribed by Semmler, Annalese B.T.; Savarimuthu Francis, Santiyagu M.; Ruddy, Alex; Rabnott, Glenn C.; Kelly, Jessie M.; Zimmerman, Paul V.; Fong, Kwun M.

Book ID
118571981
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
175 KB
Volume
41
Category
Article
ISSN
0169-5002

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The p p ! 6INK4 and p I8 genes are members of the gene famil coding for inhibitors of cyclin-dependent kinases 4 and 6. frequently deleted in many human neoplasms. To examine the role of these 3 genes in lung carcinogenesis, somatic mutations within the genes were analyzed by single-strand conformat