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Intragenic mutations of the p16INK4, p15INK4B and p18 genes in primary non-small-cell lung cancers

✍ Scribed by Marek R. Rusin; Aikou Okamoto; Mieczyslaw Chorazy; Kazimierz Czyzewski; Jolanta Harasim; Elisa A. Spillare; Koichi Hagiwara; S. Perwez Hussain; Yue Xiong; Douglas J. Demetrick; Curtis C. Harris

Publisher: John Wiley and Sons
Year: 1996
Tongue: French
Weight: 721 KB
Volume: 65
Category: Article
ISSN: 0020-7136
DOI: 10.1002/(sici)1097-0215(19960315)65:6<734::aid-ijc4>3.0.co;2-#

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✦ Synopsis

The p p ! 6INK4 and p I8 genes are members of the gene famil coding for inhibitors of cyclin-dependent kinases 4 and 6. frequently deleted in many human neoplasms. To examine the role of these 3 genes in lung carcinogenesis, somatic mutations within the genes were analyzed by single-strand conformation polymorphism and DNA sequencing in 7 I non-small-cell lung cancer (NSCLC) samples. Six somatic mutations in the pl6INK4 gene and 3 cases with a polymorphic allele were observed. Loss of heterozygosity in the p I8 gene was found in I sample. We did not find any intragenic mutations in the p15"K4B or p18 genes. We conclude that p16INK4 mutations play a role in the formation of some NSCLCs, whereas the involvement of ~1 5 " ~~~ and p18 is uncommon. o 1996 Wiley-Liss, Inc. * PIS' N z 48 and p16INK4 are located at 9p2 I, a chromosomal region 6To whom correspondence and reprint requests should be sent, at Bldg. 37, Rm.

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