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The reaction of trans-7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene with DNA involves attack at the N7-position of guanine moieties

✍ Scribed by M.R. Osborne; R.G. Harvey; P. Brookes


Book ID
113135921
Publisher
Elsevier Science
Year
1978
Tongue
English
Weight
451 KB
Volume
20
Category
Article
ISSN
0009-2797

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The reaction of (±)-7α, 8β-dihydroxy-9β,
✍ M. R. Osborne; P. Brookes; F. A. Beland; R. G. Harvey 📂 Article 📅 1976 🏛 John Wiley and Sons 🌐 French ⚖ 539 KB

## Abstract The reaction of (±)‐7α,8β‐dihydroxy‐9β,10β‐epoxy‐7,8,9,10‐tetrahydrobenzo(__a__)pyrene (BP diol epoxide) with DNA, followed by enzymatic hydrolysis and LH 20 Sephadex column chromatography, yielded products containing a purine deoxyribonucleoside linked to a 7,8,9,10‐tetrahydrobenzo(__a