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Synthesis of anti -7,8-Dihydroxy-9,10-epoxy-7,8,9,10-tetrahydro-11-methylbenzo[ a ]pyrene and Its Reaction with DNA

✍ Scribed by Lin, Jyh-Ming; Desai, Dhimant; Chung, Lehua; Hecht, Stephen S.; Amin, Shantu


Book ID
127111600
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
222 KB
Volume
12
Category
Article
ISSN
0893-228X

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The reaction of (±)-7α, 8β-dihydroxy-9β,
✍ M. R. Osborne; P. Brookes; F. A. Beland; R. G. Harvey 📂 Article 📅 1976 🏛 John Wiley and Sons 🌐 French ⚖ 539 KB

## Abstract The reaction of (±)‐7α,8β‐dihydroxy‐9β,10β‐epoxy‐7,8,9,10‐tetrahydrobenzo(__a__)pyrene (BP diol epoxide) with DNA, followed by enzymatic hydrolysis and LH 20 Sephadex column chromatography, yielded products containing a purine deoxyribonucleoside linked to a 7,8,9,10‐tetrahydrobenzo(__a