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Bifunctional catalysis in the nucleotide-catalyzed hydrolysis of (.+-.)-7.beta.,8.alpha.-dihydroxy-9.alpha.,10.alpha.-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene

✍ Scribed by Gupta, Satish C.; Islam, Nafisa B.; Whalen, Dale L.; Yagi, H.; Jerina, D. M.


Book ID
126783098
Publisher
American Chemical Society
Year
1987
Tongue
English
Weight
577 KB
Volume
52
Category
Article
ISSN
0022-3263

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The reaction of (±)-7α, 8β-dihydroxy-9β,
✍ M. R. Osborne; P. Brookes; F. A. Beland; R. G. Harvey 📂 Article 📅 1976 🏛 John Wiley and Sons 🌐 French ⚖ 539 KB

## Abstract The reaction of (±)‐7α,8β‐dihydroxy‐9β,10β‐epoxy‐7,8,9,10‐tetrahydrobenzo(__a__)pyrene (BP diol epoxide) with DNA, followed by enzymatic hydrolysis and LH 20 Sephadex column chromatography, yielded products containing a purine deoxyribonucleoside linked to a 7,8,9,10‐tetrahydrobenzo(__a