The radiosensitising effects of Iressa (ZD 1839), an EGFR tyrosine kinase inhibitor, on related bladder cancer cell lines in vitro
โ Scribed by S. Maddineni; V. Sangar; J. Hendry; C. Betts; K. O'Flynn; N. Clarke
- Book ID
- 118644330
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 222 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1569-9056
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## Abstract Selective tyrosine kinase inhibitors are regarded as promising antitumor agents for cancer treatment. Iressaยฎ (ZD1839) is an orally active, selective EGFRโTKI (epidermal growth factor receptorโtyrosine kinase inhibitor) that blocks signal transduction pathways implicated in cancer cell
Overexpression of the growth factor receptors EGFR and erbB2 occurs frequently in several human cancers and is associated with aggressive tumour behaviour and poor patient prognosis. We have investigated the effects of ZD1839 (Iressa), a novel EGFR tyrosine kinase inhibitor, on the growth, in vitro