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The EGFR-selective tyrosine kinase inhibitor ZD1839 (‘Iressa’) is an effective inhibitor of tamoxifen-resistant breast cancer growth

✍ Scribed by J. Gee; I. Hutcheson; J. Knowlden; D. Barrow; M. Harper; H. Jones; A. Wakeling; R. Nicholson

Book ID
117658822
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
192 KB
Volume
37
Category
Article
ISSN
0959-8049

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Overexpression of the growth factor receptors EGFR and erbB2 occurs frequently in several human cancers and is associated with aggressive tumour behaviour and poor patient prognosis. We have investigated the effects of ZD1839 (Iressa), a novel EGFR tyrosine kinase inhibitor, on the growth, in vitro